Oral submucous fibrosis is a condition that is mostly associated with the use of areca nut, a component of betel quid and is widespread among South Asian populations.  It produces grimness (loss of oral function as tissues stiffen and mouth opening becomes difficult) and death (when developed into squamous cell carcinoma happens). This is an extremely severe and persistent pre-cancerous disorder that damages the oral cavity as well as the pharynx. It produces submucosal tissue fibrosis and juxta-epithelial inflammatory responses. This condition also causes fibro-elastic alterations in the lamina propria, as well as epithelial atrophy and stiffness of the oral mucosa. Because of the excessive stiffness of the jaw, opening the mouth could become impossible.